Drug interactions
Irbesartan + Piroxicam
Severity: Moderate
Irbesartan and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam can reduce the antihypertensive effect of irbesartan and, in combination, may cause acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
What this interaction means in plain words
Irbesartan and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irbesartan belongs to Cardiovascular; Piroxicam belongs to Musculoskeletal.
Why it happens
NSAID blockade of vasodilatory prostaglandins reduces glomerular perfusion while the ARB dilates the efferent arteriole, impairing filtration and potassium excretion.
What to do
Monitor blood pressure, serum creatinine and potassium within the first weeks and periodically. Ensure hydration and avoid long-term NSAID use where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Piroxicam?
MediHelp rates the interaction as moderate. Irbesartan and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam can reduce the antihypertensive effect of irbesartan and, in combination, may cause acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
How serious is the interaction between Irbesartan and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium within the first weeks and periodically. Ensure hydration and avoid long-term NSAID use where possible.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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