Drug interactions
Irbesartan + Tizanidine
Severity: Moderate
Irbesartan and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine lowers blood pressure through central alpha-2 stimulation and irbesartan lowers it by blocking angiotensin II receptors. Together they can cause additive hypotension with dizziness or fainting, especially when starting or increasing doses.
What this interaction means in plain words
Irbesartan and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irbesartan belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive antihypertensive effects from central alpha-2 agonism and angiotensin II receptor blockade.
What to do
Monitor blood pressure when starting or adjusting either drug, and lower the dose if symptomatic hypotension occurs. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Tizanidine?
MediHelp rates the interaction as moderate. Irbesartan and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine lowers blood pressure through central alpha-2 stimulation and irbesartan lowers it by blocking angiotensin II receptors. Together they can cause additive hypotension with dizziness or fainting, especially when starting or increasing doses.
How serious is the interaction between Irbesartan and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or adjusting either drug, and lower the dose if symptomatic hypotension occurs. Counsel patients to rise slowly.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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