Drug interactions
Irinotecan + Rucaparib
Severity: Minor
Irinotecan and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 weakly to moderately and could alter irinotecan metabolism. Irinotecan is both activated by carboxylesterases and inactivated by CYP3A4 oxidation, so the net effect is uncertain. Overlapping myelosuppression is also possible.
What this interaction means in plain words
Irinotecan and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irinotecan belongs to Oncology; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, which may change irinotecan oxidative clearance, but the net effect is not established.
What to do
Monitor blood counts and diarrhea, and adjust the irinotecan dose if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Irinotecan with Rucaparib?
MediHelp rates the interaction as minor. Irinotecan and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP3A4 weakly to moderately and could alter irinotecan metabolism. Irinotecan is both activated by carboxylesterases and inactivated by CYP3A4 oxidation, so the net effect is uncertain. Overlapping myelosuppression is also possible.
How serious is the interaction between Irinotecan and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and diarrhea, and adjust the irinotecan dose if toxicity develops.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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