Drug interactions
Irinotecan + Stiripentol
Severity: Moderate
Irinotecan and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol both inhibits and induces CYP3A4, so its effect on irinotecan exposure is unpredictable. It may also inhibit UGT1A1, which would increase SN-38 and the risk of diarrhea and neutropenia.
What this interaction means in plain words
Irinotecan and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irinotecan belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol has mixed CYP3A4 inhibition and induction effects and may inhibit UGT1A1, altering irinotecan and SN-38 disposition.
What to do
Monitor for diarrhea and neutropenia and adjust the irinotecan dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Irinotecan with Stiripentol?
MediHelp rates the interaction as moderate. Irinotecan and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol both inhibits and induces CYP3A4, so its effect on irinotecan exposure is unpredictable. It may also inhibit UGT1A1, which would increase SN-38 and the risk of diarrhea and neutropenia.
How serious is the interaction between Irinotecan and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and neutropenia and adjust the irinotecan dose if toxicity occurs.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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