Drug interactions
Iron + Vadadustat
Severity: Moderate
Iron and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron and iron-containing binders reduce vadadustat absorption. This may lower efficacy for anemia treatment.
What this interaction means in plain words
Iron and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iron belongs to Gastrointestinal Tract; Vadadustat belongs to Endocrine.
Why it happens
Chelation of vadadustat by iron in the gut reduces absorption.
What to do
Take vadadustat at least 1 hour before oral iron or iron-containing phosphate binders. Monitor hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Other interactions of Iron
- Acetohydroxamic acid + Iron Moderate
- Aluminum hydroxide + Iron Moderate
- Baloxavir marboxil + Iron Moderate
- Calcium acetate + Iron Moderate
- Calcium carbonate + Iron Moderate
- Calcium citrate + Iron Moderate
Frequently asked questions
Can I take Iron with Vadadustat?
MediHelp rates the interaction as moderate. Iron and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron and iron-containing binders reduce vadadustat absorption. This may lower efficacy for anemia treatment.
How serious is the interaction between Iron and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take vadadustat at least 1 hour before oral iron or iron-containing phosphate binders. Monitor hemoglobin.
What other medicines interact with Vadadustat?
MediHelp also lists interactions of Vadadustat with, for example, Atorvastatin, Balsalazide, Baricitinib. The full list is on the Vadadustat page.
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