Drug interactions
Isavuconazonium + Mefloquine
Severity: Minor
Isavuconazonium and Mefloquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate, and mefloquine is a weak CYP3A4 inhibitor, so levels may rise slightly. Isavuconazole shortens the QT interval, so QT concerns are limited.
What this interaction means in plain words
Isavuconazonium and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible weak CYP3A4 inhibition by mefloquine reduces isavuconazole metabolism.
What to do
No routine adjustment is needed. Monitor for isavuconazole adverse effects such as hepatic enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Mefloquine?
MediHelp rates the interaction as minor. Isavuconazonium and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a CYP3A4 substrate, and mefloquine is a weak CYP3A4 inhibitor, so levels may rise slightly. Isavuconazole shortens the QT interval, so QT concerns are limited.
How serious is the interaction between Isavuconazonium and Mefloquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for isavuconazole adverse effects such as hepatic enzyme elevation.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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