Drug interactions
Isavuconazonium + Midazolam
Severity: Moderate
Isavuconazonium and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active form, is a moderate CYP3A4 inhibitor that increases midazolam exposure. This can prolong sedation and increase respiratory depression, especially with oral midazolam.
What this interaction means in plain words
Isavuconazonium and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Midazolam belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 metabolism of midazolam by isavuconazole.
What to do
Reduce midazolam dose, especially for oral use, and monitor sedation and respiratory function until effects wear off.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Midazolam?
MediHelp rates the interaction as moderate. Isavuconazonium and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active form, is a moderate CYP3A4 inhibitor that increases midazolam exposure. This can prolong sedation and increase respiratory depression, especially with oral midazolam.
How serious is the interaction between Isavuconazonium and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce midazolam dose, especially for oral use, and monitor sedation and respiratory function until effects wear off.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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