Drug interactions
Isavuconazonium + Mycophenolate mofetil
Severity: Moderate
Isavuconazonium and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole may inhibit UGT enzymes involved in mycophenolic acid glucuronidation, potentially raising mycophenolate exposure. Higher levels could increase myelosuppression and gastrointestinal toxicity. The effect is predicted and likely modest.
What this interaction means in plain words
Isavuconazonium and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Possible inhibition of UGT-mediated glucuronidation of mycophenolic acid by isavuconazole.
What to do
Monitor blood counts and gastrointestinal tolerability, and consider mycophenolic acid level monitoring. Reduce the mycophenolate dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Isavuconazonium and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole may inhibit UGT enzymes involved in mycophenolic acid glucuronidation, potentially raising mycophenolate exposure. Higher levels could increase myelosuppression and gastrointestinal toxicity. The effect is predicted and likely modest.
How serious is the interaction between Isavuconazonium and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and gastrointestinal tolerability, and consider mycophenolic acid level monitoring. Reduce the mycophenolate dose if toxicity appears.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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