Drug interactions
Isavuconazonium + Ribociclib
Severity: Moderate
Isavuconazonium and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active moiety, is a CYP3A4 substrate and a moderate CYP3A4 inhibitor. Ribociclib may increase isavuconazole levels, and isavuconazole may in turn raise ribociclib exposure and QT risk, since both drugs may prolong or affect QT (isavuconazole shortens it).
What this interaction means in plain words
Isavuconazonium and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Ribociclib belongs to Oncology.
Why it happens
Bidirectional CYP3A4 interaction: ribociclib inhibits isavuconazole metabolism and isavuconazole inhibits ribociclib clearance.
What to do
Monitor ECG and electrolytes, and consider lowering the ribociclib dose per labeling for CYP3A4 inhibitors. Watch for isavuconazole adverse effects such as hepatotoxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Ribociclib?
MediHelp rates the interaction as moderate. Isavuconazonium and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active moiety, is a CYP3A4 substrate and a moderate CYP3A4 inhibitor. Ribociclib may increase isavuconazole levels, and isavuconazole may in turn raise ribociclib exposure and QT risk, since both drugs may prolong or affect QT (isavuconazole shortens it).
How serious is the interaction between Isavuconazonium and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and consider lowering the ribociclib dose per labeling for CYP3A4 inhibitors. Watch for isavuconazole adverse effects such as hepatotoxicity.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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