Drug interactions
Isocarboxazid + Pregabalin
Severity: Moderate
Isocarboxazid and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin produces sedation and dizziness, and an MAO inhibitor may add to CNS depression. The combination can increase drowsiness and impair coordination, particularly in older patients.
What this interaction means in plain words
Isocarboxazid and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isocarboxazid belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism.
What to do
Use the lowest effective pregabalin dose, titrate slowly, and monitor for sedation, dizziness and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Isocarboxazid with Pregabalin?
MediHelp rates the interaction as moderate. Isocarboxazid and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pregabalin produces sedation and dizziness, and an MAO inhibitor may add to CNS depression. The combination can increase drowsiness and impair coordination, particularly in older patients.
How serious is the interaction between Isocarboxazid and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pregabalin dose, titrate slowly, and monitor for sedation, dizziness and respiratory depression.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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