Drug interactions
Isocarboxazid + Tiotropium-olodaterol
Severity: Moderate
Isocarboxazid and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Monoamine oxidase inhibitors can potentiate the cardiovascular effects of beta2-agonists such as olodaterol, causing tachycardia, palpitations, blood pressure elevation or arrhythmias. The olodaterol label advises extra caution with MAO inhibitors.
What this interaction means in plain words
Isocarboxazid and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isocarboxazid belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
MAO inhibition increases adrenergic tone, which adds to beta2-agonist cardiovascular stimulation.
What to do
Monitor heart rate, blood pressure and symptoms of arrhythmia after starting or changing doses. Use the lowest effective olodaterol dose and consider an alternative bronchodilator in patients with significant cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Isocarboxazid and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Monoamine oxidase inhibitors can potentiate the cardiovascular effects of beta2-agonists such as olodaterol, causing tachycardia, palpitations, blood pressure elevation or arrhythmias. The olodaterol label advises extra caution with MAO inhibitors.
How serious is the interaction between Isocarboxazid and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and symptoms of arrhythmia after starting or changing doses. Use the lowest effective olodaterol dose and consider an alternative bronchodilator in patients with significant cardiovascular disease.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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