Drug interactions
Isocarboxazid + Valbenazine
Severity: Major
Isocarboxazid and Valbenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine is a VMAT2 inhibitor that alters monoamine handling, and its use with MAOIs may cause unpredictable monoamine effects. This may increase serotonin syndrome or hypertensive risk or reduce valbenazine efficacy.
What this interaction means in plain words
Isocarboxazid and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isocarboxazid belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Opposing and overlapping effects on monoamine disposition: MAOIs raise synaptic monoamines while VMAT2 inhibition depletes vesicular stores.
What to do
Avoid concomitant use per labeling. Consider alternative therapy for tardive dyskinesia or chorea, and monitor for serotonin toxicity if exposure occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Isocarboxazid with Valbenazine?
MediHelp rates the interaction as major. Isocarboxazid and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valbenazine is a VMAT2 inhibitor that alters monoamine handling, and its use with MAOIs may cause unpredictable monoamine effects. This may increase serotonin syndrome or hypertensive risk or reduce valbenazine efficacy.
How serious is the interaction between Isocarboxazid and Valbenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use per labeling. Consider alternative therapy for tardive dyskinesia or chorea, and monitor for serotonin toxicity if exposure occurs.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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