Drug interactions
Isoflurane + Lenvatinib
Severity: Moderate
Isoflurane and Lenvatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenvatinib can prolong the QT interval, and isoflurane may add to this effect. The combination may raise the risk of torsades de pointes, particularly with electrolyte disturbances.
What this interaction means in plain words
Isoflurane and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Lenvatinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium, magnesium and calcium before anesthesia. Monitor the QTc perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Isoflurane with Lenvatinib?
MediHelp rates the interaction as moderate. Isoflurane and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenvatinib can prolong the QT interval, and isoflurane may add to this effect. The combination may raise the risk of torsades de pointes, particularly with electrolyte disturbances.
How serious is the interaction between Isoflurane and Lenvatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium, magnesium and calcium before anesthesia. Monitor the QTc perioperatively.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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