Drug interactions
Isoflurane + Lopinavir
Severity: Moderate
Isoflurane and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir can prolong the QT and PR intervals, and isoflurane may add to the QT effect. The combination may raise the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Isoflurane and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and correct electrolytes before anesthesia. Monitor the QTc perioperatively and continue antiretroviral therapy as advised by the HIV team.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Isoflurane with Lopinavir?
MediHelp rates the interaction as moderate. Isoflurane and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir can prolong the QT and PR intervals, and isoflurane may add to the QT effect. The combination may raise the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Isoflurane and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes before anesthesia. Monitor the QTc perioperatively and continue antiretroviral therapy as advised by the HIV team.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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