Drug interactions
Isoflurane + Midostaurin
Severity: Moderate
Isoflurane and Midostaurin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined exposure may raise the risk of torsades de pointes. The risk is greater with electrolyte disturbances or underlying cardiac disease.
What this interaction means in plain words
Isoflurane and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Midostaurin belongs to Oncology.
Why it happens
Additive prolongation of ventricular repolarization (QTc).
What to do
Obtain a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG continuously during and after the procedure, and prefer an alternative anesthetic approach if the QTc is markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Midostaurin
Frequently asked questions
Can I take Isoflurane with Midostaurin?
MediHelp rates the interaction as moderate. Isoflurane and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combined exposure may raise the risk of torsades de pointes. The risk is greater with electrolyte disturbances or underlying cardiac disease.
How serious is the interaction between Isoflurane and Midostaurin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG continuously during and after the procedure, and prefer an alternative anesthetic approach if the QTc is markedly prolonged.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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