Drug interactions
Isoflurane + Mirtazapine
Severity: Minor
Isoflurane and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval, and mirtazapine has a weak QT effect, so the combination could add to arrhythmia risk during anesthesia. The clinical significance is generally small in patients without other risk factors.
What this interaction means in plain words
Isoflurane and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoflurane belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation; the effect of each drug is small.
What to do
Continue mirtazapine perioperatively unless there are other risk factors. Check ECG and electrolytes in high-risk patients and monitor the rhythm during anesthesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Mirtazapine?
MediHelp rates the interaction as minor. Isoflurane and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoflurane can prolong the QT interval, and mirtazapine has a weak QT effect, so the combination could add to arrhythmia risk during anesthesia. The clinical significance is generally small in patients without other risk factors.
How serious is the interaction between Isoflurane and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue mirtazapine perioperatively unless there are other risk factors. Check ECG and electrolytes in high-risk patients and monitor the rhythm during anesthesia.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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