Drug interactions
Isoflurane + Ozanimod
Severity: Moderate
Isoflurane and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction, and QT effects are a theoretical concern with volatile anesthetics. Perioperative bradycardia or conduction abnormalities may be more pronounced.
What this interaction means in plain words
Isoflurane and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Additive effects on cardiac conduction and repolarization; ozanimod causes sphingosine-1-phosphate receptor-mediated bradycardia.
What to do
Check a baseline ECG and heart rate before anesthesia and monitor the ECG continuously. Have an anticholinergic available for symptomatic bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Isoflurane with Ozanimod?
MediHelp rates the interaction as moderate. Isoflurane and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction, and QT effects are a theoretical concern with volatile anesthetics. Perioperative bradycardia or conduction abnormalities may be more pronounced.
How serious is the interaction between Isoflurane and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and heart rate before anesthesia and monitor the ECG continuously. Have an anticholinergic available for symptomatic bradycardia.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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