Drug interactions
Isoflurane + Panobinostat
Severity: Major
Isoflurane and Panobinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat is associated with QT prolongation and serious arrhythmias, and isoflurane can also prolong the QT interval. Combined use may raise the risk of torsades de pointes.
What this interaction means in plain words
Isoflurane and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isoflurane belongs to Central Nervous System; Panobinostat belongs to Oncology.
Why it happens
Additive prolongation of ventricular repolarization (QTc).
What to do
Obtain a baseline ECG and correct potassium, magnesium and calcium before anesthesia. Monitor the ECG continuously and consider an alternative anesthetic technique if the QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isoflurane
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Isoflurane with Panobinostat?
MediHelp rates the interaction as major. Isoflurane and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat is associated with QT prolongation and serious arrhythmias, and isoflurane can also prolong the QT interval. Combined use may raise the risk of torsades de pointes.
How serious is the interaction between Isoflurane and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium, magnesium and calcium before anesthesia. Monitor the ECG continuously and consider an alternative anesthetic technique if the QTc is prolonged.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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