Drug interactions
Isoflurane + Sotalol
Severity: Moderate
Isoflurane and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval, and sotalol is a potent QT-prolonging agent. Under anesthesia the combination may add to torsades risk, and the negative inotropic and hypotensive effects of both drugs may also be additive.
What this interaction means in plain words
Isoflurane and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Additive QT prolongation and additive cardiovascular depression from beta-blockade and volatile anesthetic effects.
What to do
Inform the anesthesia team about sotalol use and review the preoperative ECG and electrolytes. Monitor ECG and hemodynamics continuously and have treatment for bradycardia and hypotension available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Sotalol?
MediHelp rates the interaction as moderate. Isoflurane and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval, and sotalol is a potent QT-prolonging agent. Under anesthesia the combination may add to torsades risk, and the negative inotropic and hypotensive effects of both drugs may also be additive.
How serious is the interaction between Isoflurane and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about sotalol use and review the preoperative ECG and electrolytes. Monitor ECG and hemodynamics continuously and have treatment for bradycardia and hypotension available.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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