Drug interactions
Isoflurane + Trazodone
Severity: Moderate
Isoflurane and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval and cause hypotension, and trazodone may add to both effects. The risk is mostly relevant in the perioperative period.
What this interaction means in plain words
Isoflurane and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and hypotensive effects.
What to do
Tell the anesthesia team about trazodone and monitor ECG and blood pressure during anesthesia. Maintain normal electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Trazodone?
MediHelp rates the interaction as moderate. Isoflurane and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval and cause hypotension, and trazodone may add to both effects. The risk is mostly relevant in the perioperative period.
How serious is the interaction between Isoflurane and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about trazodone and monitor ECG and blood pressure during anesthesia. Maintain normal electrolytes.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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