Drug interactions
Isoflurane + Valbenazine
Severity: Moderate
Isoflurane and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine may cause a modest QT prolongation at higher exposures, and isoflurane can also lengthen the QT interval. The combination could add to arrhythmia risk, particularly in patients with congenital long QT, bradycardia or electrolyte disturbance. Valbenazine also causes somnolence, which may add to anesthetic sedation.
What this interaction means in plain words
Isoflurane and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization, with additive CNS depression.
What to do
Review baseline ECG and correct potassium and magnesium before anesthesia. Monitor ECG during the procedure and avoid additional QT-prolonging agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Isoflurane with Valbenazine?
MediHelp rates the interaction as moderate. Isoflurane and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine may cause a modest QT prolongation at higher exposures, and isoflurane can also lengthen the QT interval. The combination could add to arrhythmia risk, particularly in patients with congenital long QT, bradycardia or electrolyte disturbance. Valbenazine also causes somnolence, which may add to anesthetic sedation.
How serious is the interaction between Isoflurane and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline ECG and correct potassium and magnesium before anesthesia. Monitor ECG during the procedure and avoid additional QT-prolonging agents.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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