Drug interactions
Isoniazid + Maraviroc
Severity: Minor
Isoniazid and Maraviroc: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak CYP3A4 inhibitor, and maraviroc is a CYP3A4 substrate. Any increase in maraviroc exposure from isoniazid is expected to be small, and the maraviroc dose reduction applies to strong inhibitors, not to isoniazid.
What this interaction means in plain words
Isoniazid and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Maraviroc belongs to Anti Virals.
Why it happens
Weak CYP3A4 inhibition by isoniazid may marginally increase maraviroc exposure.
What to do
No empirical maraviroc dose change is needed. Monitor for postural hypotension and hepatic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Isoniazid with Maraviroc?
MediHelp rates the interaction as minor. Isoniazid and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is a weak CYP3A4 inhibitor, and maraviroc is a CYP3A4 substrate. Any increase in maraviroc exposure from isoniazid is expected to be small, and the maraviroc dose reduction applies to strong inhibitors, not to isoniazid.
How serious is the interaction between Isoniazid and Maraviroc?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical maraviroc dose change is needed. Monitor for postural hypotension and hepatic adverse effects.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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