Drug interactions
Isoniazid + Montelukast
Severity: Minor
Isoniazid and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits several CYP enzymes, including CYP3A4 and CYP2C19, so montelukast exposure could rise slightly. The expected clinical impact is negligible.
What this interaction means in plain words
Isoniazid and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Montelukast belongs to Respiratory.
Why it happens
Inhibition of minor CYP pathways of montelukast metabolism by isoniazid.
What to do
No adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Montelukast?
MediHelp rates the interaction as minor. Isoniazid and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid inhibits several CYP enzymes, including CYP3A4 and CYP2C19, so montelukast exposure could rise slightly. The expected clinical impact is negligible.
How serious is the interaction between Isoniazid and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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