Drug interactions
Isoniazid + Pacritinib
Severity: Moderate
Isoniazid and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is metabolized primarily by CYP3A4, and the CYP2E1 mechanism proposed is not well supported. Isoniazid may modestly raise pacritinib exposure through CYP3A4 inhibition, potentially worsening bleeding, diarrhea, and QT effects.
What this interaction means in plain words
Isoniazid and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Pacritinib belongs to Oncology.
Why it happens
Possible inhibition of CYP3A4-mediated pacritinib metabolism; the contribution of CYP2E1 is not established.
What to do
Monitor for pacritinib adverse effects including bleeding, diarrhea, and QTc prolongation. Consider dose adjustment if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Isoniazid with Pacritinib?
MediHelp rates the interaction as moderate. Isoniazid and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib is metabolized primarily by CYP3A4, and the CYP2E1 mechanism proposed is not well supported. Isoniazid may modestly raise pacritinib exposure through CYP3A4 inhibition, potentially worsening bleeding, diarrhea, and QT effects.
How serious is the interaction between Isoniazid and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pacritinib adverse effects including bleeding, diarrhea, and QTc prolongation. Consider dose adjustment if toxicity occurs.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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