Drug interactions
Isoproterenol + Labetalol
Severity: Moderate
Isoproterenol and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks beta receptors and directly antagonizes the effects of isoproterenol, which can reduce its heart rate and bronchodilator effects. Higher isoproterenol doses may be needed, and the response can be unpredictable.
What this interaction means in plain words
Isoproterenol and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Labetalol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism: competitive beta-receptor blockade opposes isoproterenol's beta agonist actions.
What to do
Monitor heart rate, blood pressure and clinical response, and titrate isoproterenol to effect. Consider holding labetalol if isoproterenol is needed for bradycardia or bronchospasm.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Labetalol?
MediHelp rates the interaction as moderate. Isoproterenol and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol blocks beta receptors and directly antagonizes the effects of isoproterenol, which can reduce its heart rate and bronchodilator effects. Higher isoproterenol doses may be needed, and the response can be unpredictable.
How serious is the interaction between Isoproterenol and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and clinical response, and titrate isoproterenol to effect. Consider holding labetalol if isoproterenol is needed for bradycardia or bronchospasm.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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