Drug interactions
Isoproterenol + Metoprolol
Severity: Moderate
Isoproterenol and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol antagonizes the beta-adrenergic effects of isoproterenol and reduces its chronotropic, inotropic and bronchodilator action. Higher isoproterenol doses may be needed, and cardioselectivity is lost at higher doses.
What this interaction means in plain words
Isoproterenol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Metoprolol belongs to Cardiovascular.
Why it happens
Competitive pharmacodynamic antagonism at beta-adrenergic receptors.
What to do
Monitor heart rate, blood pressure and clinical response, and titrate isoproterenol to effect. Consider an alternative strategy if the beta-blocker is the cause of the bradycardia being treated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Metoprolol?
MediHelp rates the interaction as moderate. Isoproterenol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoprolol antagonizes the beta-adrenergic effects of isoproterenol and reduces its chronotropic, inotropic and bronchodilator action. Higher isoproterenol doses may be needed, and cardioselectivity is lost at higher doses.
How serious is the interaction between Isoproterenol and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and clinical response, and titrate isoproterenol to effect. Consider an alternative strategy if the beta-blocker is the cause of the bradycardia being treated.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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