Drug interactions
Isoproterenol + Perphenazine
Severity: Moderate
Isoproterenol and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol is a beta-agonist that can cause tachycardia and arrhythmias, and phenothiazines can affect cardiac conduction and repolarization. Phenothiazine alpha-blockade may also cause hypotension with reflex tachycardia. The clinical risk is poorly characterized and mainly applies to predisposed patients.
What this interaction means in plain words
Isoproterenol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Possible additive proarrhythmic and hemodynamic effects; the mechanism is not firmly established.
What to do
Monitor ECG and blood pressure when isoproterenol is given to a patient taking perphenazine. Check electrolytes and QTc in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Perphenazine?
MediHelp rates the interaction as moderate. Isoproterenol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol is a beta-agonist that can cause tachycardia and arrhythmias, and phenothiazines can affect cardiac conduction and repolarization. Phenothiazine alpha-blockade may also cause hypotension with reflex tachycardia. The clinical risk is poorly characterized and mainly applies to predisposed patients.
How serious is the interaction between Isoproterenol and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and blood pressure when isoproterenol is given to a patient taking perphenazine. Check electrolytes and QTc in patients with cardiac risk factors.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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