Drug interactions
Isosorbide dinitrate + Stiripentol
Severity: Minor
Isosorbide dinitrate and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can inhibit and induce CYP3A4, but isosorbide dinitrate is metabolised mainly by non-CYP denitration. A meaningful change in nitrate effect is therefore unlikely.
What this interaction means in plain words
Isosorbide dinitrate and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isosorbide dinitrate belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4, which is a minor pathway for isosorbide dinitrate.
What to do
No dose change is needed. Review anginal control and blood pressure if the response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Isosorbide dinitrate with Stiripentol?
MediHelp rates the interaction as minor. Isosorbide dinitrate and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol can inhibit and induce CYP3A4, but isosorbide dinitrate is metabolised mainly by non-CYP denitration. A meaningful change in nitrate effect is therefore unlikely.
How serious is the interaction between Isosorbide dinitrate and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Review anginal control and blood pressure if the response changes.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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