Drug interactions
Isotretinoin + Mifepristone
Severity: Moderate
Isotretinoin and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP2C8 and CYP2C9, which contribute to isotretinoin metabolism, so isotretinoin levels may rise. This may increase dose-related effects such as mucocutaneous dryness and hepatic effects.
What this interaction means in plain words
Isotretinoin and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isotretinoin belongs to Dermatology; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP2C8/2C9 reduces isotretinoin metabolism.
What to do
Monitor for isotretinoin adverse effects and liver enzymes and lipids; use the lowest effective isotretinoin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Isotretinoin
- Demeclocycline + Isotretinoin Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Isotretinoin + Oxytetracycline Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Aminolevulinic acid + Isotretinoin Major
- Doxycycline + Isotretinoin Major
Frequently asked questions
Can I take Isotretinoin with Mifepristone?
MediHelp rates the interaction as moderate. Isotretinoin and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP2C8 and CYP2C9, which contribute to isotretinoin metabolism, so isotretinoin levels may rise. This may increase dose-related effects such as mucocutaneous dryness and hepatic effects.
How serious is the interaction between Isotretinoin and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for isotretinoin adverse effects and liver enzymes and lipids; use the lowest effective isotretinoin dose.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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