Drug interactions
Istradefylline + Lacosamide
Severity: Minor
Istradefylline and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses weakly inhibits CYP3A4 and may raise exposure to CYP3A4 substrates. Lacosamide has multiple metabolic routes, so any rise is likely small.
What this interaction means in plain words
Istradefylline and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Lacosamide belongs to Central Nervous System.
Why it happens
Weak, dose-dependent CYP3A4 inhibition by istradefylline.
What to do
No routine adjustment needed; monitor for dizziness or PR prolongation if istradefylline 40 mg daily is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Lacosamide?
MediHelp rates the interaction as minor. Istradefylline and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at higher doses weakly inhibits CYP3A4 and may raise exposure to CYP3A4 substrates. Lacosamide has multiple metabolic routes, so any rise is likely small.
How serious is the interaction between Istradefylline and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; monitor for dizziness or PR prolongation if istradefylline 40 mg daily is used.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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