Drug interactions
Istradefylline + Methylprednisolone
Severity: Minor
Istradefylline and Methylprednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline weakly inhibits CYP3A4 and may raise exposure to CYP3A4 substrates such as methylprednisolone. The effect is expected to be modest and was not seen at 20 mg daily.
What this interaction means in plain words
Istradefylline and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Methylprednisolone belongs to Endocrine.
Why it happens
Istradefylline at higher doses inhibits CYP3A4, reducing methylprednisolone clearance.
What to do
Monitor for increased corticosteroid effects if istradefylline 40 mg daily is used and consider a methylprednisolone dose reduction.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Methylprednisolone?
MediHelp rates the interaction as minor. Istradefylline and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg daily, istradefylline weakly inhibits CYP3A4 and may raise exposure to CYP3A4 substrates such as methylprednisolone. The effect is expected to be modest and was not seen at 20 mg daily.
How serious is the interaction between Istradefylline and Methylprednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased corticosteroid effects if istradefylline 40 mg daily is used and consider a methylprednisolone dose reduction.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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