Drug interactions
Istradefylline + Nevirapine
Severity: Minor
Istradefylline and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses can raise levels of CYP3A4 substrates, but nevirapine is mainly a CYP3A4 and CYP2B6 substrate with a wide dosing range. A clinically meaningful change is possible but unproven.
What this interaction means in plain words
Istradefylline and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Nevirapine belongs to Anti Virals.
Why it happens
Istradefylline weakly inhibits CYP3A4 at 40 mg daily, which might slightly reduce nevirapine metabolism.
What to do
Monitor for nevirapine adverse effects such as rash and liver enzyme elevations, especially at the 40 mg istradefylline dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Nevirapine?
MediHelp rates the interaction as minor. Istradefylline and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at higher doses can raise levels of CYP3A4 substrates, but nevirapine is mainly a CYP3A4 and CYP2B6 substrate with a wide dosing range. A clinically meaningful change is possible but unproven.
How serious is the interaction between Istradefylline and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nevirapine adverse effects such as rash and liver enzyme elevations, especially at the 40 mg istradefylline dose.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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