Drug interactions
Istradefylline + Oxycodone
Severity: Moderate
Istradefylline and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses istradefylline inhibits CYP3A4 and can raise exposure to CYP3A4 substrates such as oxycodone, increasing opioid effects.
What this interaction means in plain words
Istradefylline and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Dose-dependent CYP3A4 inhibition by istradefylline reduces oxycodone metabolism.
What to do
Monitor for sedation and respiratory depression and consider reducing oxycodone dose if istradefylline is used at the higher dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Oxycodone?
MediHelp rates the interaction as moderate. Istradefylline and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At higher doses istradefylline inhibits CYP3A4 and can raise exposure to CYP3A4 substrates such as oxycodone, increasing opioid effects.
How serious is the interaction between Istradefylline and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and consider reducing oxycodone dose if istradefylline is used at the higher dose.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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