Drug interactions
Istradefylline + Palbociclib
Severity: Minor
Istradefylline and Palbociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg/day weakly inhibits CYP3A4 and may increase exposure to CYP3A4 substrates such as palbociclib. This could worsen neutropenia.
What this interaction means in plain words
Istradefylline and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Palbociclib belongs to Oncology.
Why it happens
Istradefylline inhibits CYP3A4 at higher doses, modestly reducing palbociclib clearance.
What to do
Keep istradefylline at 20 mg/day if possible and monitor blood counts as routinely scheduled. Consider reducing palbociclib if neutropenia emerges.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Palbociclib
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Palbociclib?
MediHelp rates the interaction as minor. Istradefylline and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at 40 mg/day weakly inhibits CYP3A4 and may increase exposure to CYP3A4 substrates such as palbociclib. This could worsen neutropenia.
How serious is the interaction between Istradefylline and Palbociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep istradefylline at 20 mg/day if possible and monitor blood counts as routinely scheduled. Consider reducing palbociclib if neutropenia emerges.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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