Drug interactions
Istradefylline + Pravastatin
Severity: Minor
Istradefylline and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at the higher dose inhibits P-glycoprotein and can increase exposure to P-gp substrates. Pravastatin is a partial P-gp substrate, so its concentrations may rise modestly.
What this interaction means in plain words
Istradefylline and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Pravastatin belongs to Cardiovascular.
Why it happens
Istradefylline inhibits intestinal P-glycoprotein efflux, increasing pravastatin absorption.
What to do
No routine adjustment is needed; monitor for muscle symptoms and consider a lower pravastatin dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Pravastatin?
MediHelp rates the interaction as minor. Istradefylline and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at the higher dose inhibits P-glycoprotein and can increase exposure to P-gp substrates. Pravastatin is a partial P-gp substrate, so its concentrations may rise modestly.
How serious is the interaction between Istradefylline and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for muscle symptoms and consider a lower pravastatin dose if they appear.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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