Drug interactions
Istradefylline + Temsirolimus
Severity: Moderate
Istradefylline and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses (40 mg/day) istradefylline raises exposure to CYP3A4 and P-gp substrates, which may increase temsirolimus and sirolimus levels. This may amplify mTOR-related toxicity.
What this interaction means in plain words
Istradefylline and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Temsirolimus belongs to Oncology.
Why it happens
Istradefylline inhibits CYP3A4 and P-glycoprotein, reducing temsirolimus clearance and efflux.
What to do
Keep istradefylline at 20 mg/day if possible and monitor for temsirolimus adverse effects; consider reducing the temsirolimus dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Temsirolimus?
MediHelp rates the interaction as moderate. Istradefylline and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At higher doses (40 mg/day) istradefylline raises exposure to CYP3A4 and P-gp substrates, which may increase temsirolimus and sirolimus levels. This may amplify mTOR-related toxicity.
How serious is the interaction between Istradefylline and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep istradefylline at 20 mg/day if possible and monitor for temsirolimus adverse effects; consider reducing the temsirolimus dose if toxicity develops.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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