Drug interactions
Istradefylline + Trazodone
Severity: Moderate
Istradefylline and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline inhibits CYP3A4 and can raise exposure to CYP3A4 substrates such as trazodone. This may cause more sedation, hypotension and QT effects.
What this interaction means in plain words
Istradefylline and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Dose-dependent CYP3A4 inhibition by istradefylline reduces trazodone clearance.
What to do
Consider reducing the trazodone dose when istradefylline is given at 40 mg daily, and monitor for sedation and dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Trazodone?
MediHelp rates the interaction as moderate. Istradefylline and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg daily, istradefylline inhibits CYP3A4 and can raise exposure to CYP3A4 substrates such as trazodone. This may cause more sedation, hypotension and QT effects.
How serious is the interaction between Istradefylline and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the trazodone dose when istradefylline is given at 40 mg daily, and monitor for sedation and dizziness.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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