Drug interactions
Istradefylline + Trimipramine
Severity: Minor
Istradefylline and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses istradefylline inhibits CYP3A4 and may increase exposure to CYP3A4 substrates. Trimipramine is partly metabolized by this pathway, so a modest rise in levels is possible, with more adverse effects.
What this interaction means in plain words
Istradefylline and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Dose-dependent CYP3A4 inhibition by istradefylline reduces trimipramine clearance.
What to do
Monitor for anticholinergic and cardiac adverse effects, particularly with the higher istradefylline dose, and consider lowering the trimipramine dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Trimipramine?
MediHelp rates the interaction as minor. Istradefylline and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At higher doses istradefylline inhibits CYP3A4 and may increase exposure to CYP3A4 substrates. Trimipramine is partly metabolized by this pathway, so a modest rise in levels is possible, with more adverse effects.
How serious is the interaction between Istradefylline and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic and cardiac adverse effects, particularly with the higher istradefylline dose, and consider lowering the trimipramine dose if they appear.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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