Drug interactions
Istradefylline + Upadacitinib
Severity: Minor
Istradefylline and Upadacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses weakly inhibits CYP3A4 and may modestly raise upadacitinib exposure. The effect is unlikely at the lower istradefylline dose.
What this interaction means in plain words
Istradefylline and Upadacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Upadacitinib belongs to Musculoskeletal.
Why it happens
Istradefylline at 40 mg/day inhibits intestinal and hepatic CYP3A4, modestly reducing upadacitinib clearance.
What to do
No dose change is typically needed with istradefylline 20 mg/day. Monitor for infection and cytopenias if the 40 mg/day dose is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Istradefylline and Upadacitinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Upadacitinib?
MediHelp rates the interaction as minor. Istradefylline and Upadacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at higher doses weakly inhibits CYP3A4 and may modestly raise upadacitinib exposure. The effect is unlikely at the lower istradefylline dose.
How serious is the interaction between Istradefylline and Upadacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is typically needed with istradefylline 20 mg/day. Monitor for infection and cytopenias if the 40 mg/day dose is used.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
