Drug interactions
Istradefylline + Vortioxetine
Severity: Minor
Istradefylline and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline weakly inhibits CYP3A4 and may modestly increase vortioxetine exposure. The effect is expected to be small because vortioxetine relies mainly on CYP2D6.
What this interaction means in plain words
Istradefylline and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses inhibits CYP3A4, reducing vortioxetine's secondary metabolic pathway.
What to do
No routine adjustment is needed; monitor tolerability, especially at the 40 mg istradefylline dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Istradefylline and Vortioxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Vortioxetine?
MediHelp rates the interaction as minor. Istradefylline and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg daily, istradefylline weakly inhibits CYP3A4 and may modestly increase vortioxetine exposure. The effect is expected to be small because vortioxetine relies mainly on CYP2D6.
How serious is the interaction between Istradefylline and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor tolerability, especially at the 40 mg istradefylline dose.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
