Drug interactions
Itraconazole + Lenacapavir
Severity: Moderate
Itraconazole and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may increase itraconazole concentrations. The inhibitory effect can persist for months after the last subcutaneous injection, so itraconazole-related adverse effects may emerge late.
What this interaction means in plain words
Itraconazole and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, reducing itraconazole metabolism.
What to do
Monitor for itraconazole toxicity such as edema, hypertension, hypokalemia and QT effects, and consider checking itraconazole levels. Remember that the effect may persist for several months after the last lenacapavir dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Itraconazole with Lenacapavir?
MediHelp rates the interaction as moderate. Itraconazole and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may increase itraconazole concentrations. The inhibitory effect can persist for months after the last subcutaneous injection, so itraconazole-related adverse effects may emerge late.
How serious is the interaction between Itraconazole and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for itraconazole toxicity such as edema, hypertension, hypokalemia and QT effects, and consider checking itraconazole levels. Remember that the effect may persist for several months after the last lenacapavir dose.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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