Drug interactions
Itraconazole + Memantine-donepezil
Severity: Moderate
Itraconazole and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 inhibitor and may raise donepezil levels, increasing cholinergic effects. Both drugs may also prolong the QT interval, adding to arrhythmia risk.
What this interaction means in plain words
Itraconazole and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Memantine-donepezil belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition reduces donepezil clearance, with additive QT prolongation.
What to do
Monitor the ECG, heart rate and cholinergic adverse effects. Consider a donepezil dose reduction if bradycardia or gastrointestinal effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Memantine-donepezil?
MediHelp rates the interaction as moderate. Itraconazole and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole is a strong CYP3A4 inhibitor and may raise donepezil levels, increasing cholinergic effects. Both drugs may also prolong the QT interval, adding to arrhythmia risk.
How serious is the interaction between Itraconazole and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG, heart rate and cholinergic adverse effects. Consider a donepezil dose reduction if bradycardia or gastrointestinal effects occur.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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