Drug interactions
Itraconazole + Oliceridine
Severity: Major
Itraconazole and Oliceridine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole increases oliceridine exposure, which may cause profound sedation and respiratory depression. Stopping the inhibitor may reduce opioid effect and cause withdrawal if the dose was lowered.
What this interaction means in plain words
Itraconazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Oliceridine belongs to Musculoskeletal.
Why it happens
Strong inhibition of CYP3A4-mediated oliceridine metabolism.
What to do
Reduce the dose or extend the dosing interval of oliceridine, and monitor closely for respiratory depression and sedation. Reassess the dose if itraconazole is discontinued.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Itraconazole with Oliceridine?
MediHelp rates the interaction as major. Itraconazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole increases oliceridine exposure, which may cause profound sedation and respiratory depression. Stopping the inhibitor may reduce opioid effect and cause withdrawal if the dose was lowered.
How serious is the interaction between Itraconazole and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the dose or extend the dosing interval of oliceridine, and monitor closely for respiratory depression and sedation. Reassess the dose if itraconazole is discontinued.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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