Drug interactions
Itraconazole + Paricalcitol
Severity: Minor
Itraconazole and Paricalcitol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paricalcitol is partly metabolized by CYP3A4, and itraconazole may increase its exposure. This may lead to hypercalcemia or excessive suppression of parathyroid hormone.
What this interaction means in plain words
Itraconazole and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Paricalcitol belongs to Musculoskeletal.
Why it happens
CYP3A4 inhibition reduces paricalcitol clearance.
What to do
Monitor serum calcium, phosphate and PTH, and reduce the paricalcitol dose if hypercalcemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Paricalcitol
- Carbamazepine + Paricalcitol Moderate
- Cholestyramine + Paricalcitol Moderate
- Clarithromycin + Paricalcitol Moderate
- Digoxin + Paricalcitol Moderate
- Ketoconazole + Paricalcitol Moderate
- Paricalcitol + Posaconazole Moderate
Frequently asked questions
Can I take Itraconazole with Paricalcitol?
MediHelp rates the interaction as minor. Itraconazole and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paricalcitol is partly metabolized by CYP3A4, and itraconazole may increase its exposure. This may lead to hypercalcemia or excessive suppression of parathyroid hormone.
How serious is the interaction between Itraconazole and Paricalcitol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, phosphate and PTH, and reduce the paricalcitol dose if hypercalcemia develops.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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