Drug interactions
Itraconazole + Prednisone
Severity: Moderate
Itraconazole and Prednisone: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole strongly inhibits CYP3A4 and can raise exposure to prednisolone, though prednisone is less affected than methylprednisolone or dexamethasone. This may increase corticosteroid effects such as hyperglycemia and adrenal suppression.
What this interaction means in plain words
Itraconazole and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Prednisone belongs to Endocrine.
Why it happens
Itraconazole inhibits CYP3A4 and P-glycoprotein, reducing clearance of prednisolone.
What to do
Monitor for corticosteroid excess such as hyperglycemia, edema and hypertension, and reduce the prednisone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
- Prednisone - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Prednisone?
MediHelp rates the interaction as moderate. Itraconazole and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole strongly inhibits CYP3A4 and can raise exposure to prednisolone, though prednisone is less affected than methylprednisolone or dexamethasone. This may increase corticosteroid effects such as hyperglycemia and adrenal suppression.
How serious is the interaction between Itraconazole and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess such as hyperglycemia, edema and hypertension, and reduce the prednisone dose if needed.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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