Drug interactions
Itraconazole + Primaquine
Severity: Moderate
Itraconazole and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may raise primaquine concentrations, and both drugs have some potential to prolong the QTc interval. This may increase the risk of adverse effects including gastrointestinal upset and arrhythmia in susceptible patients.
What this interaction means in plain words
Itraconazole and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Primaquine belongs to Anti Parasitic.
Why it happens
CYP3A4 inhibition may alter primaquine metabolism, combined with additive effects on cardiac repolarization.
What to do
Obtain an ECG in patients with cardiac risk factors and correct electrolytes. Monitor for hemolysis and methemoglobinemia as per primaquine care.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Frequently asked questions
Can I take Itraconazole with Primaquine?
MediHelp rates the interaction as moderate. Itraconazole and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may raise primaquine concentrations, and both drugs have some potential to prolong the QTc interval. This may increase the risk of adverse effects including gastrointestinal upset and arrhythmia in susceptible patients.
How serious is the interaction between Itraconazole and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with cardiac risk factors and correct electrolytes. Monitor for hemolysis and methemoglobinemia as per primaquine care.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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