Drug interactions
Itraconazole + Roflumilast
Severity: Moderate
Itraconazole and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 inhibitor and may raise roflumilast and active metabolite exposure. This may increase adverse effects such as diarrhea, weight loss, headache and insomnia.
What this interaction means in plain words
Itraconazole and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Roflumilast belongs to Respiratory.
Why it happens
Itraconazole inhibits CYP3A4-mediated metabolism of roflumilast.
What to do
Monitor for roflumilast adverse effects and weight loss during combined use; reassess need if tolerability worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Roflumilast?
MediHelp rates the interaction as moderate. Itraconazole and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole is a strong CYP3A4 inhibitor and may raise roflumilast and active metabolite exposure. This may increase adverse effects such as diarrhea, weight loss, headache and insomnia.
How serious is the interaction between Itraconazole and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for roflumilast adverse effects and weight loss during combined use; reassess need if tolerability worsens.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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