Drug interactions
Itraconazole + Sertraline
Severity: Moderate
Itraconazole and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to QTc prolongation, though sertraline carries a low risk at usual doses. Combined use may modestly add to arrhythmia risk in vulnerable patients.
What this interaction means in plain words
Itraconazole and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Sertraline belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization; itraconazole may modestly raise sertraline levels via CYP3A4 inhibition.
What to do
Consider an ECG in patients with cardiac disease or electrolyte disturbance, and correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Itraconazole with Sertraline?
MediHelp rates the interaction as moderate. Itraconazole and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been linked to QTc prolongation, though sertraline carries a low risk at usual doses. Combined use may modestly add to arrhythmia risk in vulnerable patients.
How serious is the interaction between Itraconazole and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG in patients with cardiac disease or electrolyte disturbance, and correct potassium and magnesium.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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