Drug interactions
Itraconazole + Tamsulosin
Severity: Major
Itraconazole and Tamsulosin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 inhibitor and can substantially increase tamsulosin concentrations. This raises the risk of marked hypotension, dizziness and syncope.
What this interaction means in plain words
Itraconazole and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Tamsulosin belongs to Genitourinary.
Why it happens
Itraconazole strongly inhibits CYP3A4, the main pathway of tamsulosin metabolism, and increases its systemic exposure.
What to do
Avoid the combination; labeling advises against tamsulosin with strong CYP3A4 inhibitors. If antifungal therapy is needed, consider an alternative or temporarily hold tamsulosin with blood pressure monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Tamsulosin?
MediHelp rates the interaction as major. Itraconazole and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole is a strong CYP3A4 inhibitor and can substantially increase tamsulosin concentrations. This raises the risk of marked hypotension, dizziness and syncope.
How serious is the interaction between Itraconazole and Tamsulosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling advises against tamsulosin with strong CYP3A4 inhibitors. If antifungal therapy is needed, consider an alternative or temporarily hold tamsulosin with blood pressure monitoring.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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