Drug interactions
Itraconazole + Terbinafine
Severity: Minor
Itraconazole and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two antifungals are often combined in onychomycosis, and terbinafine is mainly cleared by multiple pathways, so clinically important changes in its exposure are not expected. Itraconazole may be slightly affected by terbinafine, but this is rarely significant.
What this interaction means in plain words
Itraconazole and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Terbinafine belongs to Anti Fungals.
Why it happens
Minor pharmacokinetic effects; terbinafine has multiple clearance routes, so CYP3A4 inhibition has little impact.
What to do
No routine adjustment is required; monitor for hepatic adverse effects and clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Itraconazole with Terbinafine?
MediHelp rates the interaction as minor. Itraconazole and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The two antifungals are often combined in onychomycosis, and terbinafine is mainly cleared by multiple pathways, so clinically important changes in its exposure are not expected. Itraconazole may be slightly affected by terbinafine, but this is rarely significant.
How serious is the interaction between Itraconazole and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor for hepatic adverse effects and clinical response.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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